Програма академiчних обмiнiв iменi Фулбрайта в Українi

1 грудня 2015

Total Synthesis of Natural Products as a Driving Force for Chemical and Biological Discovery

Total Synthesis of Natural Products as a Driving Force for Chemical and Biological Discovery

The Fulbright Program in Ukraine is pleased to invite you to a seminar "Total Synthesis of Natural Products as a Driving Force for Chemical and Biological Discovery" by Fulbright Ph.D. student 2011-2016 Nataliia Shymanska, to be held on Tuesday, December 1, 2015, 6:00 p.m., at the Fulbright Office (20 Esplanadna Street, Suite 904, M "Palats Sportu", Kyiv).

Total Synthesis of Natural Products as a Driving Force for Chemical and Biological Discovery

Untreatable infections, a result of multi-drug resistance of pathogenic bacteria (Enterococcus spp., Staphylococcus aureus, Pseudomonas aeruginosa etc.) to antibiotics, continue to be a major threat to public health and modern medicine.

The numbers are alarming: out of 400,000 instances of infections caused by resistant pathogens 25,000 were lethal (Europe, 2007); 54% of isolated bacterial strains of Staphylococcus Aureus from Ukrainian hospitals in 2010 were resistant to antimicrobial treatments.

Despite the world-wide pressing clinical need, the majority of chemical scaffolds of currently prescribed antibiotics were discovered between 1940 and 1960 - the "golden age of antibiotics". Owing to the lack of creative approaches to identify new compounds, the drug-discovery industry is losing interest in antibiotic research.

Natural products have always been the mainstay source of antibiotics with new modes of action. Recently, marine environment has proven a fertile source of bioactive and chemically diverse molecules. Bioassay-guided fractionation of Synoicum Pulmonaria (a sub-arctic ascidian collected off the Norwegian Coast) led to isolation of a novel family of natural products named synoxazolidinones. They have promising antimicrobial activity (with unknown mechanism of action and selectivity profile). In addition, rare heterocyclic scaffold presents an interesting synthetic challenge.

We developed a rapid and diastereoselective synthesis of the synoxazolidinone family of natural products. The short reaction sequence of our approaches allows for rapid generation of analogues and chemical probes around the 4-oxazolidinone, and regioisomeric scaffolds which were ultimately converted to novel β-amino acids (containing quaternary stereocenter) employing Claisen rearrangement.

Nataliia SHYMANSKA obtained a B.Sc. in Chemistry  (2010) from Kyiv Taras Shevchenko National University.  In 2011, she received the Fulbright grant to pursue a Ph.D. degree in Chemistry at North Carolina State University (Raleigh, NC). Currently, Nataliia is working on her Ph.D. thesis ‘'Development of Synthetic Approaches to Novel Antimicrobial Compounds, Family of  Synoxazolidinones" under the supervision of Professor Joshua Pierce.

The seminar will be conducted in English.

Please register online to attend the lecture.